McMaster University

Firestone Institute for
Respiratory Health

Scope of Search

FIRH Research

FIRH Publications

  • 2017
  • 2016
  • 2015
  • 2014
  • 2013
  • 2012

2017 Publications

2016 Publications

  • Ayaub EA, Kolb PS, Mohammed-Ali Z, Tat V, Murphy J, Bellaye PS, Shimbori C, Boivin FJ, Lai R, Lynn EG, Lhotak S, Bridgewater D, Kolb MR, Inman MD, Dickhout JG, Austin RC, Ask K. GRP78 and CHOP modulate macrophage apoptosis and the development of bleomycin-induced pulmonary fibrosis. J Pathol 2016; 239: 411-425
  • Bharwani A, Mian MF, Foster JA, Surette MG, Bienenstock J, Forsythe P. Structural & functional consequences of chronic psychosocial stress on the microbiome & host. Psychoneuroendocrinology 2016; 63: 217-227
  • Canonica GW, Senna G, Mitchell PD, O'Byrne PM, Passalacqua G, Varricchi G. Therapeutic interventions in severe asthma. World Allergy Organ J 2016; 9: 40
  • Dessalle K, Narayanan V, Kyoh S, Mogas A, Halayko AJ, Nair P, Baglole CJ, Eidelman DH, Ludwig MS, Hamid Q. Human bronchial and parenchymal fibroblasts display differences in basal inflammatory phenotype and response to IL-17A. Clin Exp Allergy 2016; 46: 945-956
  • Dvorkin-Gheva A, Vanderstocken G, Yildirim AO, Brandsma CA, Obeidat M, Bosse Y, Hassell JA, Stampfli MR. Total particulate matter concentration skews cigarette smoke's gene expression profile. ERJ Open Res 2016; 2
  • El-Gammal A, Oliveria JP, Howie K, Watson R, Mitchell P, Chen R, Baatjes A, Smith S, Al-Sajee D, Hawke TJ, Killian KJ, Gauvreau GM, O'Byrne PM. Allergen-induced Changes in Bone Marrow and Airway Dendritic Cells in Subjects with Asthma. Am J Respir Crit Care Med 2016; 194: 169-177
  • Forsythe P. Microbes taming mast cells: Implications for allergic inflammation and beyond. Eur J Pharmacol 2016; 778: 169-175
  • Forsythe P, Kunze W, Bienenstock J. Moody microbes or fecal phrenology: what do we know about the microbiota-gut-brain axis? BMC Med 2016; 14: 58
  • Froese AR, Shimbori C, Bellaye PS, Inman M, Obex S, Fatima S, Jenkins G, Gauldie J, Ask K, Kolb M. Stretch-induced Activation of Transforming Growth Factor-beta1 in Pulmonary Fibrosis. Am J Respir Crit Care Med 2016; 194: 84-96
  • Gupta S, Moosa D, MacPherson A, Allen C, Tamari IE. Effects of a 12-month multi-faceted mentoring intervention on knowledge, quality, and usage of spirometry in primary care: a before-and-after study. BMC Pulm Med 2016; 16: 56
  • Hambly N, Alawfi F, Mehta S. Pulmonary hypertension: diagnostic approach and optimal management. CMAJ 2016; 188: 804-812
  • Hancox RJ, Gray AR, Poulton R, Sears MR. The Effect of Cigarette Smoking on Lung Function in Young Adults with Asthma. Am J Respir Crit Care Med 2016; 194: 276-284
  • Haw TJ, Starkey MR, Nair PM, Pavlidis S, Liu G, Nguyen DH, Hsu AC, Hanish I, Kim RY, Collison AM, Inman MD, Wark PA, Foster PS, Knight DA, Mattes J, Yagita H, Adcock IM, Horvat JC, Hansbro PM. A pathogenic role for tumor necrosis factor-related apoptosis-inducing ligand in chronic obstructive pulmonary disease. Mucosal Immunol 2016; 9: 859-872
  • Kerstjens HA, O'Byrne PM. Tiotropium for the treatment of asthma: a drug safety evaluation. Expert Opin Drug Saf 2016; 15: 1115-1124
  • Kolb M, Jenkins G, Richeldi L. Study the past to divine the future. Confucius' wisdom doesn't work for idiopathic pulmonary fibrosis. Thorax 2016; 71: 399-400
  • Kolb M, White ES, Gauldie J. Mucking around in the Genome: MUC5B in Idiopathic Pulmonary Fibrosis. Am J Respir Crit Care Med 2016; 193: 355-357
  • Kreuter M, Wijsenbeek MS, Vasakova M, Spagnolo P, Kolb M, Costabel U, Weycker D, Kirchgaessler KU, Maher TM. Unfavourable effects of medically indicated oral anticoagulants on survival in idiopathic pulmonary fibrosis: methodological concerns. Eur Respir J 2016; 48: 1524-1526
  • Kreuter M, Wijsenbeek MS, Vasakova M, Spagnolo P, Kolb M, Costabel U, Weycker D, Kirchgaessler KU, Maher TM. Unfavourable effects of medically indicated oral anticoagulants on survival in idiopathic pulmonary fibrosis. Eur Respir J 2016; 47: 1776-1784
  • Kreuter M, Wuyts W, Renzoni E, Koschel D, Maher TM, Kolb M, Weycker D, Spagnolo P, Kirchgaessler KU, Herth FJ, Costabel U. Anti-acid treatment in patients with IPF: interpret results from post-hoc, subgroup, and exploratory analyses with great caution - Authors' reply. Lancet Respir Med 2016; 4: e48
  • Kreuter M, Wuyts W, Renzoni E, Koschel D, Maher TM, Kolb M, Weycker D, Spagnolo P, Kirchgaessler KU, Herth FJ, Costabel U. Antacid therapy and disease outcomes in idiopathic pulmonary fibrosis: a pooled analysis. Lancet Respir Med 2016; 4: 381-389
  • Leclercq S, Forsythe P, Bienenstock J. Posttraumatic Stress Disorder: Does the Gut Microbiome Hold the Key? Can J Psychiatry 2016; 61: 204-213
  • Lopez-Rodriguez E, Boden C, Echaide M, Perez-Gil J, Kolb M, Gauldie J, Maus UA, Ochs M, Knudsen L. Surfactant dysfunction during overexpression of TGF-beta1 precedes profibrotic lung remodeling in vivo. Am J Physiol Lung Cell Mol Physiol 2016; 310: L1260-1271
  • Lynch SJ, Sears MR, Hancox RJ. Thumb-Sucking, Nail-Biting, and Atopic Sensitization, Asthma, and Hay Fever. Pediatrics 2016; 138
  • Martinez FJ, Rabe KF, Sethi S, Pizzichini E, McIvor A, Anzueto A, Alagappan VK, Siddiqui S, Rekeda L, Miller CJ, Zetterstrand S, Reisner C, Rennard SI. Effect of Roflumilast and Inhaled Corticosteroid/Long-Acting beta2-Agonist on Chronic Obstructive Pulmonary Disease Exacerbations (RE(2)SPOND). A Randomized Clinical Trial. Am J Respir Crit Care Med 2016; 194: 559-567
  • Mitchell PD, El-Gammal AI, O'Byrne PM. Emerging monoclonal antibodies as targeted innovative therapeutic approaches to asthma. Clin Pharmacol Ther 2016; 99: 38-48
  • Mitchell PD, O'Byrne PM. Epithelial Derived Cytokines in Asthma. Chest 2016
  • Mitchell PD, O'Byrne PM. Surfactant Protein-D and Asthma. Chest 2016; 149: 1121-1122
  • Moldaver DM, Larche M, Rudulier CD. An update on lymphocyte subtypes in Asthma and Airway Disease. Chest 2016
  • Morissette MC, Gao Y, Shen P, Thayaparan D, Berube JC, Pare PD, Brandsma CA, Hao K, Bosse Y, Ettinger R, Herbst R, Humbles AA, Kolbeck R, Zhong N, Chen R, Stampfli MR. Role of BAFF in pulmonary autoantibody responses induced by chronic cigarette smoke exposure in mice. Physiol Rep 2016; 4
  • O'Byrne PM, Metev H, Puu M, Richter K, Keen C, Uddin M, Larsson B, Cullberg M, Nair P. Efficacy and safety of a CXCR2 antagonist, AZD5069, in patients with uncontrolled persistent asthma: a randomised, double-blind, placebo-controlled trial. Lancet Respir Med 2016; 4: 797-806
  • Rahman M, Mukherjee S, Sheng W, Nilius B, Janssen LJ. Electrophysiological characterization of voltage-dependent calcium currents and TRPV4 currents in human pulmonary fibroblasts. Am J Physiol Lung Cell Mol Physiol 2016; 310: L603-614
  • Rennard SI, Martinez FJ, Rabe KF, Sethi S, Pizzichini E, McIvor A, Siddiqui S, Anzueto A, Zhu H. Effects of roflumilast in COPD patients receiving inhaled corticosteroid/long-acting beta2-agonist fixed-dose combination: RE(2)SPOND rationale and study design. Int J Chron Obstruct Pulmon Dis 2016; 11: 1921-1928
  • Rudulier CD, Larche M, Moldaver D. Treatment with anti-cytokine monoclonal antibodies can potentiate the target cytokine rather than neutralize its activity. Allergy 2016; 71: 283-285
  • Salter BM, Manzoor F, Beaudin S, Kjarsgaard M, Nair P, Gauvreau GM, Sehmi R. Dysregulation of Vascular Endothelial Progenitor Cells Lung-Homing in Subjects with COPD. Can Respir J 2016; 2016: 1472823
  • Salter BM, Nusca G, Tworek D, Oliveria JP, Smith SG, Watson RM, Scime T, Obminski C, Sehmi R, Gauvreau GM. Expression of activation markers in circulating basophils and the relationship to allergen-induced bronchoconstriction in subjects with mild allergic asthma. J Allergy Clin Immunol 2016; 137: 936-938 e937
  • Sastre J, Fabbri LM, Price D, Wahn HU, Bousquet J, Fish JE, Murphy K, Sears MR. Insights, attitudes, and perceptions about asthma and its treatment: a multinational survey of patients from Europe and Canada. World Allergy Organ J 2016; 9: 13
  • Sehmi R, Smith SG, Kjarsgaard M, Radford K, Boulet LP, Lemiere C, Prazma CM, Ortega H, Martin JG, Nair P. Role of local eosinophilopoietic processes in the development of airway eosinophilia in prednisone-dependent severe asthma. Clin Exp Allergy 2016; 46: 793-802
  • Shen P, Morissette MC, Vanderstocken G, Gao Y, Hassan M, Roos A, Thayaparan D, Merlano M, Dorrington MG, Nikota JK, Bauer CM, Kwiecien JM, Labiris R, Bowdish DM, Stevenson CS, Stampfli MR. Cigarette Smoke Attenuates the Nasal Host Response to Streptococcus pneumoniae and Predisposes to Invasive Pneumococcal Disease in Mice. Infect Immun 2016; 84: 1536-1547
  • Shimbori C, Bellaye PS, Xia J, Gauldie J, Ask K, Ramos C, Becerril C, Pardo A, Selman M, Kolb M. Fibroblast growth factor-1 attenuates TGF-beta1-induced lung fibrosis. J Pathol 2016; 240: 197-210
  • Soliman M, Steacy L, Thiele J, Adams D, Neighbour H, Ellis AK. Administering multiple cumulative allergen challenges: An alternative nasal allergen challenge protocol for the Allergic Rhinitis-Clinical Investigator Collaborative. Ann Allergy Asthma Immunol 2016; 117: 326-328
  • Sutherland TJ, McLachlan CR, Sears MR, Poulton R, Hancox RJ. The relationship between body fat and respiratory function in young adults. Eur Respir J 2016; 48: 734-747
  • Thayaparan D, Shen P, Stampfli MR, Morissette MC. Induction of pulmonary antibodies against oxidized lipids in mice exposed to cigarette smoke. Respir Res 2016; 17: 97
  • Tworek D, Smith SG, Salter BM, Baatjes AJ, Scime T, Watson R, Obminski C, Gauvreau GM, O'Byrne PM. IL-25 Receptor Expression on Airway Dendritic Cells after Allergen Challenge in Subjects with Asthma. Am J Respir Crit Care Med 2016; 193: 957-964
  • Wang H, Chen R, Xie J, Zhang Q, Deng Y, Zeng Q, Zhu Z, Ding M, Lai Z, Kolb M, O'Byrne P, Chen R, Zhong N. A 43-year-old man with cough, expectoration and recurrent wheezing. J Thorac Dis 2016; 8: 3468-3477
  • Wolfe MG, Zhang Q, Hui C, Radford K, Nair P, Brennan JD. Development of a functional point-of-need diagnostic for myeloperoxidase detection to identify neutrophilic bronchitis. Analyst 2016; 141: 6438-6443
  • Yaghi A, Dolovich MB. Airway Epithelial Cell Cilia and Obstructive Lung Disease. Cells 2016; 5

2015 Publications

  • Arrieta M-C, Stiemsma LT, Dimitriu PA, Thorson L, Russell S, Yurist-Doutsch S, Kuzeljevic B, Gold MJ, Britton HM, Lefebvre DL, Subbarao P, Mandhane P, Becker A, McNagny KM, Sears MR, Kollmann T, the CHILD Study Investigators, Mohn WW, Turvey SE, Finlay BB.  Early life microbial and metabolic alterations affect risk of childhood asthma.  Sci Transl Med 2015;7:307ra152
  • Azad MB, Konya T, Guttman DS, Field CJ, Sears MR, HayGlass KT, Mandhane PJ, Turvey SE, Subbarao P, Becker AB, Scott JA, Kozyrskyj AL; CHILD Study Investigators. Infant gut microbiota and food sensitization: associations in the first year of life. Clin Exp Allergy 2015;45:632-64
  • Baatjes AJ, Smith SG, Watson R, Howie K, Murphy D, Larché M, Denburg JA, Inman MD, O’Byrne PM.  T-regulatory cell phenotypes in peripheral blood and bronchoalveolar lavage from non-asthmatic and asthmatic subjects.  Clin Exp Allergy 2015; 45:1654-62
  • Baatjes AJ, Smith SG, Dua B, Watson R, Gauvreau GM, O’Byrne PM. The effect of anti-OX40L or anti-TSLP treatment on the frequency of peripheral blood T regulatory cells in allergic asthma.  Allergy 2015; 70:1505-8
  • Bateman ED; Buhl R, O’Byrne PM, Humbert M,  Reddel HK, Sears MR, Jenkins C, Harrison TW, Quirce S, Peterson S, Eriksson G. Development and validation of a novel asthma exacerbation risk score. J Allergy Clin Immunol: 2015; 135:1457-64
  • Bateman ED, O'Byrne PM, Buhl R, Rabe K. Roflumilast for asthma: weighing the evidence. Pulm Pharmacol Ther 2015; 35:S1-S3
  • Bateman ED, Bousquet J, Aubier M, Bredenbröker D, O'Byrne PM. Roflumilast for asthma: Efficacy findings in non-placebo-controlled comparator and dosing studies.  Pulm Pharmacol Ther 2015; 35:S11-S19
  • Bernstein DI, Bateman ED, Woodcock A, Toler WT, Forth R,  Jacques L, Nunn C, O'Byrne PM. Fluticasone furoate (FF)/vilanterol (100/25 mcg or 200/25 mcg) or FF (100 mcg) in persistent asthma. J Asthma; 52:1073-83
  • Boulet L-P, O’Byrne PM. Asthma and Exercise-induced Bronchoconstriction in Athletes. New Engl J Med 2015; 372:641-8
  • Boulet L-P, Gauvreau GM, Boulay M-E, O’Byrne PM, Cockcroft DW. Alllergen-induced early and late asthmatic responses to inhaled seasonal and perennial allergens.  Clin Exp Allergy  2015; 45:1647-53
  • Boulet L-P, Gauvreau GM, Cockcroft DW, Davis B, Vachon L4, Cormier Y, O’Byrne PM.  Effects of ASM-024, a modulator of acetylcholine receptor function on airway responsiveness and allergen-induced responses in mild asthmatics.  Can Respir J 2015: 22:230-4
  • Brannan JD, Larsson J, Alkhabaz A, Balgoma D, Otis J, Delin I, Dahlén B, Wheelock CE,  Nair P, Dahlén S-E, O’Byrne PM. Effect of omega-3 fatty acids on bronchial hyperesponsiveness, sputum eosinophilia and mast cell mediators in asthma.  Chest 2015; 147:397-405
  • Brightling C,  Chanez P, Leigh R, O’Byrne PM, Korn S, She D, May RD, Streicher K, Ranade K, Piper E. Efficacy and safety of tralokinumab in patients with uncontrolled severe asthma: a randomised, double-blind,placebo-controlled, phase 2b trial.  Lancet Resp Med 2015; 3:692-701
  • Gauvreau GM, El-Gammal AI, O’Byrne PM. Allergen-induced airway responses.  Eur Respir J  2015; 46:819-31
  • Gauvreau Gail M, O’Byrne Paul M, Boulet Louis-Philippe, Wang Ying, Cockcroft Donald, Bigler Jeannette, FitzGerald J. Mark, Boedigheimer Michael, Davis Beth E, Dias Clapton, Gorski Kevin S, Smith Lynn, Bautista Edgar, Comeau Michael R, Leigh Richard, and Parnes Jane R. Effects of an Anti-TSLP Antibody on Allergen-Induced Asthmatic Responses. The New England Journal of Medicine. 370;22
  • Gauvreau GM, Boulet L-P, Leigh R, Cockcroft DW, Killian KJ, Davis BE,  Deschesnes F, Watson RM, Swystun V, Wessman P, Jorup C, Aurivillius M, O’Byrne PM. A Non-Steroidal Glucocorticoid Receptor Agonist Inhibits Allergen-Induced Late Asthmatic Responses.  Am J Respir Crit Care Med 2015; 191:161-7
  • Gauvreau GM, Janssen LJ, Killian KJ, O’Byrne PM. The effects of repeated bronchoprovocation on lung function in asthmatics.  Annals ATS 2015; 12:1589-91
  • Haahtela T, Selroos O, O’Byrne PM. Revisiting early intervention in adult asthma.  ERJ Open res 2015; 1:00022-2015
  • Hancox RJ, Shin HH, Gray AR, Poulton R, Sears MR. Effects of quitting cannabis on respiratory symptoms. Eur Respir J 2015;46:80-87
  • Kinoshita Takashi, Baatjes Adrian, Smith Steven G, Dua Benny, Watson Richard, Kawayama Tomotaka, Larche Mark, Gauvreau Gail M, and O’Byrne Paul M. Natural regulatory T cells in isolated early responders compared with dual responders with allergic asthma. J ALLERGY CLIN IMMUNOL. Volume 133, Number 3
  • Kolb PS, Ayaub EA, Zhou W, Yum V, Dickhout JG, Ask K. The therapeutic effects of 4-Phenylbutyric acid in maintain proteostasis.International Journal of Bichemistry and Cell Biology.doi: 0.1016/j.biocel.2015.01.015. [Epub ahead of print].PMID: 25660369
  • Moraes TJ, Lefebvre DL, Chooniedass R, Becker AB, Brook JR, Denburg J, HayGlass KT, Hegele RG, Kollmann TR, Macri J, Mandhane PJ, Scott JA, Subbarao P, Takaro TK, Duncan JD, Sears MR, Befus AD and the CHILD Study investigators. The Canadian Healthy Infant Longitudinal Development birth cohort study: biological samples and biobanking. Paediatr and Perinat Epidemiol 2015;29:84-92
  • O’Byrne PM, D’Urzo T, Beck E, Fležar M, Gahlemann M, Hart L, Blahova Z,  Toorawa R, Beeh K-M. Dose finding of once-daily treatment with olodaterol, a novel long-acting β2-agonist, in patients with asthma.  Respir Research 2015, 16:97.  DOI: 10.1186/s12931-015-0249-8
  • O’Byrne PM, Tworek D. Timing is everything: targeting IgE to reduce asthma exacerbation risk.  J Allergy Clin Immunol 2015; 136:1486-7
  • Reddel HK, Bateman ED, Becker A, Boulet L-P, Cruz AA, Drazen JM, Haahtela T, Hurd SS, Inoue H, de Jongste JC, Lemanske RF, Jr., Levy ML, O'Byrne PM, Paggiaro P, Pedersen SE, Pizzichini E, Soto-Quiroz M, Szefler SJ, Wong GWK, FitzGerald JM. A summary of the new GINA strategy: a roadmap to asthma control Eur Respir J 2015; 46:622-39
  • Persaud RR, Azad MB, Chari RS, Sears MR, Becker AB, Kozyrskyj AL and the CHILD Study Investigators.  Perinatal antibiotic exposure of neonates in Canada and associated risk factors: a population-based study. J Matern Fetal Neonatal Med 2015;28:1190-1195
  • Sbihi H, Allen RW, Becker A, Brook JR, Mandhane P, Scott JA, Sears MR, Subbarao P, Takaro TK, Turvey SE, Brauer M. Perinatal exposure to traffic-related air pollution and atopy at 1 year of age in a multi-center Canadian birth cohort study. Environ Health Perspect 2015;123:902-908
  • Sears MR. Is the aging airway less responsive to treatment?  Am J Respir Crit Care Med. 2015;192:529-530
  • Sears MR. Predicting asthma outcomes. J Allergy Clin Immunol 2015;136:829-836
  • Sears MR. Smoking, asthma, chronic airflow obstruction and COPD. Eur Respir J 2015; 45:586-588
  • Smith SG, Gugilla A, Merim K, Irshad A, Tang W, Kinoshita T, Watson B, Oliveria J-P, O'Byrne PM,  Gauvreau GM, Sehmi R. Thymic stromal lymphopoietin and IL-33 modulate migration of hematopoietic progenitor cells in patients with allergic asthma. J Allergy Clin Immunol: 2015; 135:1594-602
  • Subbarao P, Anand SS, Becker AB, Befus AD, Brauer M, Brook JR, Denburg JA, HayGlass KT, Kobor MS, Kollmann TR, Kozyrskyj AL, Lou WY, Mandhane PJ, Miller GE, Moraes TJ, Pare PD, Scott JA, Takaro TK, Turvey SE, Duncan JM, Lefebvre DL, Sears MR; CHILD Study investigators (including O’Byrne PM). The Canadian Healthy Infant Longitudinal Development (CHILD) Study: examining developmental origins of allergy and asthma. Thorax 2015; 70:998-1000
  • Takaro TK, Scott JA, Allen RW, Anand SS, Becker AB, Befus AD, Brauer M, Duncan J, Lefebvre DL, Lou W, Mandhane PJ, McLean KE, Miller G, Sbihi H, Shu H, Subbarao P , Turvey SE, Wheeler AJ, Zeng L, Sears MR, Brook JR and the CHILD Study investigators. The Canadian Healthy Infant Longitudinal Development (CHILD) birth cohort study: assessment of environmental exposures. J Expo Sci Environ Epidemiol 2015;25:580-592
  • Azad MB, Konya T, Persaud RR, Guttman DS, Chari RS, Field CJ, Sears MR, Mandhane PJ, Turvey SE, Subbarao P, Becker AB, Scott JA, Kozyrskyj AL; CHILD Study Investigators.  Impact of maternal intrapartum antibiotics, method of birth and breastfeeding on gut microbiota during the first year of life: a prospective cohort study.  BJOG 2015 Sept 28 (epub)
  • Knippenberg S, Ueberberg B, Maus R, Bohling J, Ding N, Tort Tarres M, Hoymann HG, Jonigk D, Izykowski N, Paton JC, Ogunniyi AD, Lindig S, Bauer M, Welte T, Seeger W, Guenther A, Sisson TH, Gauldie J, Kolb M*, Maus UA*. Streptococcus pneumoniae triggers progression of pulmonary fibrosis through pneumolysin. Thorax. 2015 Jul;70(7):636-46. [* joint last authorship]
  • Luo Y*, Xu W*, Chen H, Warburton D, Dong R, Qian B, Selman M, Gauldie J, Kolb M, Shi W. A novel profibrotic mechanism mediated by TGFbeta-stimulated collagen prolyl hydroxylase expression in fibrotic lung mesenchymal cells. J Pathology. 2015 Jul;236(3):384-94
  • Forbes B, Bäckman P, Christopher D, Dolovich M, Li BV, Morgan B. In Vitro Testing for Orally Inhaled Products: Developments in Science-Based Regulatory Approaches. AAPS J. 2015 May 5. [Epub ahead of print] PMID: 25940082
  • Roos AB, Sandén C, Mori M, Bjermer L, Stampfli MR, Erjefält JS. IL-17A is Elevated in End-stage COPD and Contributes to Cigarette Smoke-induced Lymphoid Neogenesis. Am J Respir Crit Care Med. 2015 Apr 6. [Epub ahead of print]
  • Janssen LJ, Mukherjee S, Ask K, Calcium-signalling and ionic mechanisms in human pulmonary fibroblasts.Am J Respir Cell Mol Biol. 2015 Mar 18. PMID: 25785898
  • Mukherjee S, Ayaub E, Murphy J, Kolb M, Ask K, Janssen LJ. Nifedipine Attenuates Bleomycin-Induced Fibrosis By Blocking Calcium Oscillations. American Journal of Respiratory Cell and Molecular Biology.Am J Respir Cell Mol Biol. 2015 February. PMID: 25664495
  • Ask K, Kolb, MRJ. Challenges in Drug Development for Chronic Lung Disease – Mission Impossible? Respirology, 2015 Jan; 20 (1):13-14. PMID: 25470316
  • Morissette MC, Shen P, Thayaparan D, Stämpfli MR. Eur Respir J. Impacts of peroxisome proliferator-activated receptor-γ activation on cigarette smoke-induced exacerbated response to bacteria. 2015 Jan;45(1):191-200
  • Adamko D, Nair P, Mayers I, Tsuyuki R, Regush S, Rowe BH. Urine Metabolomic Profiling of Adults with Asthma and COPD. J Allergy Clin Immunol 2015 (in press)
  • Chu DK, Al-Garawi A, Llop-Guervara A, Pillai R, Radford K, Calhoun WJ, Nair P, Jordana M. Therapeutic potential of anti-IL-6 therapies in granulocytic airway inflammation. Allergy Asthma Clin Immunol 2015 (in press)
  • Cox C, Kjarsgaard M, Cox G, Surette MG, Nair P. A multi-dimensional approach to the management of severe asthma: inflammometry, molecular microbiology, and bronchial thermoplasty, Can Respir J 2015 (in press)
  • El-Gammal A, Oliveria J-P, Howie K, Watson R, Mitchell P, Chen R, Baatjes A, Smith S,  Al-Sajee D, Hawke T, Killian KJ, Gauvreau GM, O’Byrne PM. Allergen-induced changes in bone marrow and airway dendritic cells in asthmatic subjects. Am J Respir Crit Care Med (in press)
  • Mitchell PD, O’Byrne PM. Surfactant protein-D and asthma. Chest (in press)
  • Mohammed-Ali Z, Cruz GL, Lu C, Carlisle RE, Werner KE, Ask K. and Dickhout JG. Development of a model of chronic kidney disease (CKD) in the C57BL/6 mouse with properties of progressive human CKD. Biomed Research International Article ID 172302 (in press)
  • Sheridan JA, Zago M, Nair P, Li PZ, Bourbeau J, Tan WC, Hamid Q, Eidelman DH, Benedetti AL, Baglole CJ. Decreased expression of the NF-kappaB family member RelB in lung fibroblasts from Smokers with and without COPD potentiates cigarette smoke-induced COX-2 expression. Respir Res 2015 (in press)
  • Smith SG, Chen R, Kjarsgaard M, Huang C, Oliveria JP, O’Byrne P, Gauvreau G, Boulet LP, Lemiere C, Martin JG, Nair P, Sehmi R. Increased Numbers of Activated Group 2 Innate Lymphoid Cells in the Airways of Severe Asthmatics with Persistent Airway Eosinophilia. J Allergy Clin Immunol 2015 (in press)
  • Tworek D, Smith SG, Salter BM, Baatjes AJ, Scime T, Watson R, Obminski C, Gauvreau GM,  O’Byrne PM. Interleukin 25 receptor (IL-17RB) expression by dendritic cells after inhaled allergen challenge in asthmatic subjects.  Am J Respir Crit Care Med (in press)

2014 Publications

  • Gauvreau Gail M, Harris Jeffrey M, Boulet Louis-Philippe, Scheerens Heleen, Fitzgerald J. Mark, Putnam Wendy S, Cockcroft Donald W, Davis Beth E, Leigh Richard, Zheng Yanan, Dahlén Barbro, Wang Yehong, Maciuca Romeo, Mayers Irvin, Liao X. Charlene, Wu Lawren C, Matthews John G, OByrne Paul M. Targeting membrane-expressed IgE B cell receptor with an antibody to the M1 prime epitope reduces IgE production. Science Translational Medicine. July 2014 Vol 6 Issue 243 (print ISSN 1946-6234; online ISSN 1946-6242).
  • Bellaye PS, Wettstein G, Burgy O, Besnard V, Joannes A, Colas J, Causse S, Marchal-Somme J, Fabre A, Crestani B, Kolb M, Gauldie J, Camus P, Garrido C, Bonniaud P. The small heat-shock protein alphaB-crystallin is essential for the nuclear localization of Smad4: impact on pulmonary fibrosis. The Journal of pathology 2014; 232: 458-472.
  • Berschneider B, Ellwanger DC, Baarsma HA, Thiel C, Shimbori C, White ES, Kolb M, Neth P, Konigshoff M. miR-92a regulates TGF-beta1-induced WISP1 expression in pulmonary fibrosis. The international journal of biochemistry & cell biology 2014; 53C: 432-441.
  • Gauvreau GM, Boulet LP, Cockcroft DW, FitzGerald JM, Mayers I, Carlsten C, Laviolette M, Killian KJ, Davis BE, Larche M, Kipling C, Dua B, Mosesova S, Putnam W, Zheng Y, Scheerens H, McClintock D, Matthews JG, O'Byrne PM. OX40L blockade and allergen-induced airway responses in subjects with mild asthma. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2014; 44: 29-37.
  • Gauvreau Gail M, Harris Jeffrey M, Boulet Louis-Philippe, Scheerens Heleen, Fitzgerald J. Mark, Putnam Wendy S, Cockcroft Donald W, Davis Beth E, Leigh Richard, Zheng Yanan, Dahlén Barbro, Wang Yehong, Maciuca Romeo, Mayers Irvin, Liao X. Charlene, Wu Lawren C, Matthews John G, OByrne Paul M. Targeting membrane-expressed IgE B cell receptor with an antibody to the M1 prime epitope reduces IgE production. Science Translational Medicine. July 2014 Vol 6 Issue 243 (print ISSN 1946-6234; online ISSN 1946-6242).
  • Guzman J, Oen K, Tucker LB, Huber AM, Shiff N, Boire G, Scuccimarri R, Berard R, Tse SM, Morishita K, Stringer E, Johnson N, Levy DM, Duffy KW, Cabral DA, Rosenberg AM, Larche M, Dancey P, Petty RE, Laxer RM, Silverman E, Miettunen P, Chetaille AL, Haddad E, Houghton K, Spiegel L, Turvey SE, Schmeling H, Lang B, Ellsworth J, Ramsey S, Bruns A, Campillo S, Benseler S, Chedeville G, Schneider R, Yeung R, Duffy CM, for the Re A-Oi. The outcomes of juvenile idiopathic arthritis in children managed with contemporary treatments: results from the ReACCh-Out cohort. Annals of the rheumatic diseases 2014.
  • Hui CC, Murphy DM, Neighbour H, Al-Sayegh M, O'Byrne S, Thong B, Denburg JA, Larche M. T cell-mediated induction of thymic stromal lymphopoietin in differentiated human primary bronchial epithelial cells. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2014; 44: 953-964.
  • Kinoshita T, Baatjes A, Smith SG, Dua B, Watson R, Kawayama T, Larche M, Gauvreau GM, O'Byrne PM. Natural regulatory T cells in isolated early responders compared with dual responders with allergic asthma. The Journal of allergy and clinical immunology 2014; 133: 696-703.
  • Kolb M, Collard HR. Staging of idiopathic pulmonary fibrosis: past, present and future. European respiratory review : an official journal of the European Respiratory Society 2014; 23: 220-224.
  • Moldaver DM, Bharhani MS, Wattie JN, Ellis R, Neighbour H, Lloyd CM, Inman MD, Larche M. Amelioration of ovalbumin-induced allergic airway disease following Der p 1 peptide immunotherapy is not associated with induction of IL-35. Mucosal immunology 2014; 7: 379-390.
  • Richeldi L, Cottin V, Flaherty KR, Kolb M, Inoue Y, Raghu G, Taniguchi H, Hansell DM, Nicholson AG, Le Maulf F, Stowasser S, Collard HR. Design of the INPULSIS trials: Two phase 3 trials of nintedanib in patients with idiopathic pulmonary fibrosis. Respiratory medicine 2014; 108: 1023-1030.
  • Richeldi L, du Bois RM, Raghu G, Azuma A, Brown KK, Costabel U, Cottin V, Flaherty KR, Hansell DM, Inoue Y, Kim DS, Kolb M, Nicholson AG, Noble PW, Selman M, Taniguchi H, Brun M, Le Maulf F, Girard M, Stowasser S, Schlenker-Herceg R, Disse B, Collard HR, Investigators IT. Efficacy and safety of nintedanib in idiopathic pulmonary fibrosis. The New England Journal of Medicine 2014; 370: 2071-2082.
  • Sivapalan N, Wattie J, Inman MD, Sehmi R. Lung-homing of endothelial progenitor cells and airway vascularization is only partially dependant on eosinophils in a house dust mite-exposed mouse model of allergic asthma. PLoS One. 2014 Oct 3;9(10).
  • Venkatesan N, Tsuchiya K, Kolb M, Farkas L, Bourhim M, Ouzzine M, Ludwig MS. Glycosyltransferases and glycosaminoglycans in bleomycin and transforming growth factor-beta1-induced pulmonary fibrosis. American journal of respiratory cell and molecular biology 2014; 50: 583-594.

2013 Publications

  • Baroke E, Gauldie J, Kolb M. New treatment and markers of prognosis for idiopathic pulmonary fibrosis: lessons learned from translational research. Expert review of respiratory medicine 2013; 7: 465-478.
  • Borensztajn K, Crestani B, Kolb M. Idiopathic pulmonary fibrosis: from epithelial injury to biomarkers--insights from the bench side. Respiration; international review of thoracic diseases 2013; 86: 441-452.
  • Farkas L, Kolb M. Vascular repair and regeneration as a therapeutic target for pulmonary arterial hypertension. Respiration; international review of thoracic diseases 2013; 85: 355-364.
  • Johnston, Neil W, Lambert Kim, Hussack Patricia, Gerhardsson de Verdier Maria, Higenbottam Tim, Lewis Jonathan, Newbold Paul, Jenkins Martins, Norman Geoff R, Coyle Peter V, and McIvor R Andrew. Detection of COPD Exacerbations and Compliance with Patient Reported Daily Symptom Diaries Using a SmartPhone-Based Information System.Chest 2013 Aug;144(2):507-14.
  • Kolb M, Shargall Y. Lung surgery in interstitial lung disease-a safe and useful procedure? Journal of thoracic disease 2013; 5: 375-377.
  • Maharaj S, Shimbori C, Kolb M. Fibrocytes in pulmonary fibrosis: a brief synopsis. European respiratory review : an official journal of the European Respiratory Society 2013; 22: 552-557.
  • Mukherjee S, Duan F, Kolb MR, Janssen LJ. Platelet derived growth factor-evoked Ca2+ wave and matrix gene expression through phospholipase C in human pulmonary fibroblast. The international journal of biochemistry & cell biology 2013; 45: 1516-1524.
  • Nazi I, Kelton JG, Larche M, Snider DP, Heddle NM, Crowther MA, Cook RJ, Tinmouth AT, Mangel J, Arnold DM. The effect of rituximab on vaccine responses in patients with immune thrombocytopenia. Blood 2013; 122: 1946-1953.
  • Patel D, Couroux P, Hickey P, Salapatek AM, Laidler P, Larche M, Hafner RP. Fel d 1-derived peptide antigen desensitization shows a persistent treatment effect 1 year after the start of dosing: a randomized, placebo-controlled study. The Journal of allergy and clinical immunology 2013; 131: 103-109 e101-107.
  • Richeldi L, Collard HR, du Bois RM, Jenkins G, Kolb M, Maher TM, Raghu G, Vancheri C, Laurent GJ. Mapping the future for pulmonary fibrosis: report from the 17th International Colloquium on Lung and Airway Fibrosis. The European respiratory journal 2013; 42: 230-238.
  • Shiff NJ, Brant R, Guzman J, Cabral DA, Huber AM, Miettunen P, Roth J, Scuccimarri R, Alos N, Atkinson SA, Collet JP, Couch R, Cummings EA, Dent PB, Ellsworth J, Hay J, Houghton K, Jurencak R, Lang B, Larche M, Leblanc C, Rodd C, Saint-Cyr C, Stein R, Stephure D, Taback S, Rauch F, Ward LM, Canadian Steroid-associated Osteoporosis in the Pediatric Population C. Glucocorticoid-related changes in body mass index among children and adolescents with rheumatic diseases. Arthritis care & research 2013; 65: 113-121.
  • Shimbori C, Gauldie J, Kolb M. Extracellular matrix microenvironment contributes actively to pulmonary fibrosis. Current opinion in pulmonary medicine 2013; 19: 446-452.
  • Simms E, Kjarsgaard M, Denis S, Hargreave FE, Nair P, Larche M. Cytokine responses of peripheral blood mononuclear cells to allergen do not identify asthma or asthma phenotypes. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2013; 43: 1226-1235.
  • Vaughan K, Peters B, Larche M, Pomes A, Broide D, Sette A. Strategies to query and display allergy-derived epitope data from the immune epitope database. International archives of allergy and immunology 2013; 160: 334-345.
  • Wettstein G, Bellaye PS, Kolb M, Hammann A, Crestani B, Soler P, Marchal-Somme J, Hazoume A, Gauldie J, Gunther A, Micheau O, Gleave M, Camus P, Garrido C, Bonniaud P. Inhibition of HSP27 blocks fibrosis development and EMT features by promoting Snail degradation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2013; 27: 1549-1560.

2012 Publications

  • DeLuca Patrick F, Johnston Neil, and Buist Steve. The Code Red Project: Engaging Communities in Health System Change in Hamilton, Canada. Social Indicators Research 2012;108 (2):317-327.
  • Ghayur A, Liu L, Kolb M, Chawla A, Lambe S, Kapoor A, Margetts PJ. Adenovirus-mediated gene transfer of TGF-beta1 to the renal glomeruli leads to proteinuria. The American journal of pathology 2012; 180: 940-951.
  • Hanumegowda C, Farkas L, Kolb M. Angiogenesis in pulmonary fibrosis: too much or not enough? Chest 2012; 142: 200-207.
  • Maharaj SS, Baroke E, Gauldie J, Kolb MR. Fibrocytes in chronic lung disease--facts and controversies. Pulmonary pharmacology & therapeutics 2012; 25: 263-267.
  • Mukherjee S, Kolb MR, Duan F, Janssen LJ. Transforming growth factor-beta evokes Ca2+ waves and enhances gene expression in human pulmonary fibroblasts. American journal of respiratory cell and molecular biology 2012; 46: 757-764.
  • Punia N, Smith S, Thomson JV, Irshad A, Nair P, Sehmi R. Interleukin-4 and interleukin-13 prime migrational responses of haemopoietic progenitor cells to stromal cell-derived factor-1α. Clin Exp Allergy. 2012 Feb;42(2):255-64.
  • Shamji MH, Ljorring C, Francis JN, Calderon MA, Larche M, Kimber I, Frew AJ, Ipsen H, Lund K, Wurtzen PA, Durham SR. Functional rather than immunoreactive levels of IgG4 correlate closely with clinical response to grass pollen immunotherapy. Allergy 2012; 67: 217-226.
  • Xu B, Chen H, Xu W, Zhang W, Buckley S, Zheng SG, Warburton D, Kolb M, Gauldie J, Shi W. Molecular mechanisms of MMP9 overexpression and its role in emphysema pathogenesis of Smad3-deficient mice. American journal of physiology Lung cellular and molecular physiology 2012; 303: L89-96.
  • Doyle TM, Ellis R, Park HJ, Inman MD, Sehmi R. Modulating progenitor accumulation attenuates lung angiogenesis in a mouse model of asthma. Eur Respir J. 2011 Sep;38(3):679-87.
  • Imaoka H, Punia N, Irshad A, Ying S, Corrigan CJ, Howie K, O'Byrne PM, Gauvreau GM, Sehmi R. Lung homing of endothelial progenitor cells in humans with asthma after allergen challenge. Am J Respir Crit Care Med. 2011 Oct 1;184(7):771-8.